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Down Syndrome Therapy: New Nanomaterial Exhibits Promise

Scientists on the Texas A&M College Well being Science Heart (Texas A&M Well being) have found {that a} nano-sized carbon materials derived from the oxidation of carbon-rich sources could possibly be used to deal with Down syndrome and different problems related to excessive ranges of hydrogen sulfide.

Hydrogen sulfide (H2S) is principally generally known as a byproduct of petroleum manufacturing that’s characterised by a “rotten egg” scent. This noxious gasoline can also be naturally produced from the anaerobic decomposition, or fermentation, of natural matter – when micro organism break down animal manure, meals wastes and different natural matter within the absence of oxygen. Hydrogen sulfide is synthesized in residing organisms, the place it performs an important function in bone, mind, liver and kidney operate, in addition to regulating the dilation of blood vessels and supplementing the electron transport chain.

One of the crucial well-known situations related to excessive ranges of hydrogen sulfide is Down syndrome. This genetic dysfunction is related to a decline in operate of many methods over time, together with the musculoskeletal and nervous methods. Earlier research have hypothesized that lowering the degrees of circulating H2S might enhance operate in people with Down syndrome. Nonetheless, hydrogen sulfide is important for regular organic operate, so straight inhibiting synthesizing enzymes could possibly be detrimental.

An revolutionary and collaborative research led by Dr. Thomas A. Kent, the Robert A. Welch Chair Professor on the Texas A&M Well being Institute of Biosciences and Know-how and the Texas A&M College Faculty of Medication, reveals how a nano-sized carbon materials derived from the oxidation of assorted carbon-rich sources can act as a mediator of a number of therapeutic reactions and enhance outcomes in experimental fashions starting from stroke, bleeding, trauma and mitochondrial toxins. This paper, printed within the high-impact journal Superior Supplies, highlights the power of the carbon nanomaterial to enhance operate and survival in Down syndrome-derived cells.

The analysis describes how readily synthesized carbon nanomaterials can present a novel method to deal with problems of poisonous ranges of hydrogen sulfide in problems like Down syndrome and lots of others. Fairly than blocking its manufacturing, hydrogen sulfide is transformed into its metabolites that supply many favorable features comparable to modifying proteins to enhance their means to behave as antioxidants. These supplies act as artificial nano-sized enzymes, termed nanozymes, that to this point haven’t proven any obvious toxicity in a number of totally different experimental fashions and are nicely tolerated whereas defending from each acute and power accidents.

“We’re enthusiastic about this analysis as a result of we imagine we’ve got found a method to deal with many problems utilizing carbon-based supplies and an easy, easy synthesis technique,” Kent mentioned. “We hope that these supplies will present a brand new method to treating problems of excessive hydrogen sulfide, by changing them to useful metabolites as exemplified by Down syndrome.

“We maintain discovering new actions, all of which to this point are favorable and could also be solely the tip of the iceberg as to what these supplies can do to assist vital organic features below situations during which they’re threatened,” he continued.

The authors of this research intend to take these supplies to marketplace for use in therapies and at the moment have a patent pending. Researchers from Texas A&M College, Rice College, UTHealth, Indiana College Faculty of Medication-South Bend, and Houston Methodist Hospital co-authored this research. This work is funded by the Welch Basis and Nationwide Institutes of Well being.




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